2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.
Identifieur interne : 000118 ( Main/Exploration ); précédent : 000117; suivant : 0001192009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.
Auteurs : James J. Jung [Canada] ; Ruxandra Pinto [Canada] ; Ryan Zarychanski [Canada] ; Deborah J. Cook [Canada] ; Philippe Jouvet [Canada] ; John C. Marshall [Canada] ; Anand Kumar [Canada] ; Jennifer Long [Canada] ; Rachel Rodin ; Robert A. Fowler [Canada]Source :
- PloS one [ 1932-6203 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- Adulte, Adulte d'âge moyen, Canada, Femelle, Grippe humaine, Groupes ethniques, Humains, Mâle.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- MESH :
- geographic : Canada.
- complications : Influenza, Human.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Ethnic Groups, Female, Humans, Male, Middle Aged, Outcome Assessment, Health Care.
Abstract
BACKGROUND
Preliminary studies suggested that Aboriginal Canadians had disproportionately higher rates of infection, hospitalization, and critical illness due to pandemic Influenza A(H1N1)pdm09.
METHODS
We used a prospective cohort study of critically ill patients with laboratory confirmed or probable H1N1 infection in Canada between April 16 2009 and April 12 2010. Baseline characteristics, medical interventions, clinical course and outcomes were compared between Aboriginal and non-Aboriginal patients. The primary outcome was hospital mortality.
RESULTS
Of 647 critically ill adult patients with known ethnicity, 81 (12.5%) were Aboriginal, 566 (87.5%) were non-Aboriginal. Aboriginal patients were younger (mean [SD] age 40.7[13.7] v. 49.0[14.9] years, p < 0.001) and more frequently female (64.2% v. 51.1%, p = 0.027). Rates of any co-morbid illnesses (Aboriginal v. non-Aboriginal, 92.6% v. 91.0%, p = 0.63), time from symptom onset to hospital admission (median [interquartile range] 4 [2-7] v. 4 [2-7] days, p = 0.84), time to ICU admission (5 [3-8] v.5 [3-8] days, p = 0.91), and severity of illness (mean APACHE II score (19.9 [9.6] v. 21.1 [9.9], p = 0.33) were similar. A similar proportion of Aboriginal patients received antiviral medication before ICU admission than non-Aboriginal patients (91.4% v. 93.8%, p = 0.40). Among Aboriginal versus non-Aboriginal patients, the need for mechanical ventilation (93.8% v. 88.6%, p = 0.15), ventilator-free days (14 [3-23] v. 17 [0-24], p = 0.62), durations of stay in ICU (13[7-19.5] v. 11 [5-8] days, p = 0.05), hospital (19 [12.5-33.5] v. 18 [11-35] days, p = 0.63), and hospital mortality were similar (19.8% v. 22.6%, p = 0.56). In multiple logistic regression analyses, higher APACHE II score (1.06; 1.04-1.09, p<0.001) was independently associated with an increased risk of death; antiviral treatment with a lower risk of death (0.34; 0.15 - 0.78, p = 0.01). Ethnicity was not associated with mortality.
INTERPRETATION
During the 2009-2010 Influenza A (H1N1) pandemic, Aboriginal and non-Aboriginal Canadians with H1N1-related critical illness had a similar risk of death, after adjusting for potential confounding factors.
DOI: 10.1371/journal.pone.0184013
PubMed: 29049285
Affiliations:
- Canada
- Manitoba, Ontario
- Hamilton (Ontario), Toronto, Winnipeg
- Université McMaster, Université de Toronto, Université du Manitoba
Links toward previous steps (curation, corpus...)
Le document en format XML
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Fowler</name><affiliation wicri:level="1"><nlm:affiliation>University of Toronto Departments of Medicine and Critical Care Medicine; Sunnybrook Hospital Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto Departments of Medicine and Critical Care Medicine; Sunnybrook Hospital Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29049285</idno><idno type="pmid">29049285</idno><idno type="doi">10.1371/journal.pone.0184013</idno><idno type="wicri:Area/Main/Corpus">000073</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000073</idno><idno type="wicri:Area/Main/Curation">000073</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000073</idno><idno type="wicri:Area/Main/Exploration">000073</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.</title><author><name sortKey="Jung, James J" sort="Jung, James J" uniqKey="Jung J" first="James J" last="Jung">James J. Jung</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Faculty of Medicine. Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Faculty of Medicine. Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Pinto, Ruxandra" sort="Pinto, Ruxandra" uniqKey="Pinto R" first="Ruxandra" last="Pinto">Ruxandra Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Zarychanski, Ryan" sort="Zarychanski, Ryan" uniqKey="Zarychanski R" first="Ryan" last="Zarychanski">Ryan Zarychanski</name><affiliation wicri:level="4"><nlm:affiliation>University of Manitoba, CancerCare Manitoba, Winnipeg MB Canada.</nlm:affiliation><orgName type="university">Université du Manitoba</orgName><country>Canada</country><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Cook, Deborah J" sort="Cook, Deborah J" uniqKey="Cook D" first="Deborah J" last="Cook">Deborah J. Cook</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Jouvet, Philippe" sort="Jouvet, Philippe" uniqKey="Jouvet P" first="Philippe" last="Jouvet">Philippe Jouvet</name><affiliation wicri:level="1"><nlm:affiliation>Le Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Le Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Marshall, John C" sort="Marshall, John C" uniqKey="Marshall J" first="John C" last="Marshall">John C. Marshall</name><affiliation wicri:level="1"><nlm:affiliation>St. Michael's Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>St. Michael's Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Anand" sort="Kumar, Anand" uniqKey="Kumar A" first="Anand" last="Kumar">Anand Kumar</name><affiliation wicri:level="1"><nlm:affiliation>University of Manitoba Health Sciences Centre, Section of Critical Care Medicine, Winnipeg MB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Manitoba Health Sciences Centre, Section of Critical Care Medicine, Winnipeg MB</wicri:regionArea><wicri:noRegion>Winnipeg MB</wicri:noRegion></affiliation></author><author><name sortKey="Long, Jennifer" sort="Long, Jennifer" uniqKey="Long J" first="Jennifer" last="Long">Jennifer Long</name><affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Rodin, Rachel" sort="Rodin, Rachel" uniqKey="Rodin R" first="Rachel" last="Rodin">Rachel Rodin</name><affiliation><nlm:affiliation>Public Health Agency of Canada, Ottawa Canada.</nlm:affiliation><wicri:noCountry code="subField">Ottawa Canada</wicri:noCountry></affiliation></author><author><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><affiliation wicri:level="1"><nlm:affiliation>University of Toronto Departments of Medicine and Critical Care Medicine; Sunnybrook Hospital Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto Departments of Medicine and Critical Care Medicine; Sunnybrook Hospital Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Canada</term><term>Ethnic Groups</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza, Human (complications)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment, Health Care</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (virologie)</term><term>Groupes ethniques</term><term>Humains</term><term>Mâle</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Ethnic Groups</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment, Health Care</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada</term><term>Femelle</term><term>Grippe humaine</term><term>Groupes ethniques</term><term>Humains</term><term>Mâle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Preliminary studies suggested that Aboriginal Canadians had disproportionately higher rates of infection, hospitalization, and critical illness due to pandemic Influenza A(H1N1)pdm09.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We used a prospective cohort study of critically ill patients with laboratory confirmed or probable H1N1 infection in Canada between April 16 2009 and April 12 2010. Baseline characteristics, medical interventions, clinical course and outcomes were compared between Aboriginal and non-Aboriginal patients. The primary outcome was hospital mortality.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Of 647 critically ill adult patients with known ethnicity, 81 (12.5%) were Aboriginal, 566 (87.5%) were non-Aboriginal. Aboriginal patients were younger (mean [SD] age 40.7[13.7] v. 49.0[14.9] years, p < 0.001) and more frequently female (64.2% v. 51.1%, p = 0.027). Rates of any co-morbid illnesses (Aboriginal v. non-Aboriginal, 92.6% v. 91.0%, p = 0.63), time from symptom onset to hospital admission (median [interquartile range] 4 [2-7] v. 4 [2-7] days, p = 0.84), time to ICU admission (5 [3-8] v.5 [3-8] days, p = 0.91), and severity of illness (mean APACHE II score (19.9 [9.6] v. 21.1 [9.9], p = 0.33) were similar. A similar proportion of Aboriginal patients received antiviral medication before ICU admission than non-Aboriginal patients (91.4% v. 93.8%, p = 0.40). Among Aboriginal versus non-Aboriginal patients, the need for mechanical ventilation (93.8% v. 88.6%, p = 0.15), ventilator-free days (14 [3-23] v. 17 [0-24], p = 0.62), durations of stay in ICU (13[7-19.5] v. 11 [5-8] days, p = 0.05), hospital (19 [12.5-33.5] v. 18 [11-35] days, p = 0.63), and hospital mortality were similar (19.8% v. 22.6%, p = 0.56). In multiple logistic regression analyses, higher APACHE II score (1.06; 1.04-1.09, p<0.001) was independently associated with an increased risk of death; antiviral treatment with a lower risk of death (0.34; 0.15 - 0.78, p = 0.01). Ethnicity was not associated with mortality.</p></div><div type="abstract" xml:lang="en"><p><b>INTERPRETATION</b></p><p>During the 2009-2010 Influenza A (H1N1) pandemic, Aboriginal and non-Aboriginal Canadians with H1N1-related critical illness had a similar risk of death, after adjusting for potential confounding factors.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29049285</PMID><DateCompleted><Year>2017</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>10</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.</ArticleTitle><Pagination><MedlinePgn>e0184013</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0184013</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Preliminary studies suggested that Aboriginal Canadians had disproportionately higher rates of infection, hospitalization, and critical illness due to pandemic Influenza A(H1N1)pdm09.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used a prospective cohort study of critically ill patients with laboratory confirmed or probable H1N1 infection in Canada between April 16 2009 and April 12 2010. Baseline characteristics, medical interventions, clinical course and outcomes were compared between Aboriginal and non-Aboriginal patients. The primary outcome was hospital mortality.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 647 critically ill adult patients with known ethnicity, 81 (12.5%) were Aboriginal, 566 (87.5%) were non-Aboriginal. Aboriginal patients were younger (mean [SD] age 40.7[13.7] v. 49.0[14.9] years, p < 0.001) and more frequently female (64.2% v. 51.1%, p = 0.027). Rates of any co-morbid illnesses (Aboriginal v. non-Aboriginal, 92.6% v. 91.0%, p = 0.63), time from symptom onset to hospital admission (median [interquartile range] 4 [2-7] v. 4 [2-7] days, p = 0.84), time to ICU admission (5 [3-8] v.5 [3-8] days, p = 0.91), and severity of illness (mean APACHE II score (19.9 [9.6] v. 21.1 [9.9], p = 0.33) were similar. A similar proportion of Aboriginal patients received antiviral medication before ICU admission than non-Aboriginal patients (91.4% v. 93.8%, p = 0.40). Among Aboriginal versus non-Aboriginal patients, the need for mechanical ventilation (93.8% v. 88.6%, p = 0.15), ventilator-free days (14 [3-23] v. 17 [0-24], p = 0.62), durations of stay in ICU (13[7-19.5] v. 11 [5-8] days, p = 0.05), hospital (19 [12.5-33.5] v. 18 [11-35] days, p = 0.63), and hospital mortality were similar (19.8% v. 22.6%, p = 0.56). In multiple logistic regression analyses, higher APACHE II score (1.06; 1.04-1.09, p<0.001) was independently associated with an increased risk of death; antiviral treatment with a lower risk of death (0.34; 0.15 - 0.78, p = 0.01). Ethnicity was not associated with mortality.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">During the 2009-2010 Influenza A (H1N1) pandemic, Aboriginal and non-Aboriginal Canadians with H1N1-related critical illness had a similar risk of death, after adjusting for potential confounding factors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jung</LastName><ForeName>James J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>University of Toronto, Faculty of Medicine. Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinto</LastName><ForeName>Ruxandra</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zarychanski</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Manitoba, CancerCare Manitoba, Winnipeg MB Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cook</LastName><ForeName>Deborah J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Departments of Clinical Epidemiology and Biostatistics and Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jouvet</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Le Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marshall</LastName><ForeName>John C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>St. Michael's Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Anand</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>University of Manitoba Health Sciences Centre, Section of Critical Care Medicine, Winnipeg MB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Long</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine; Sunnybrook Hospital; Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodin</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Public Health Agency of Canada, Ottawa Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fowler</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>University of Toronto Departments of Medicine and Critical Care Medicine; Sunnybrook Hospital Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Canadian Critical Care Trials Group H1N1 Collaborative</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005006" MajorTopicYN="N">Ethnic Groups</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017063" MajorTopicYN="N">Outcome Assessment, Health Care</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>08</Month><Day>16</Day></PubMedPubDate><PubMedPubDate 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Toronto</li><li>Université du Manitoba</li></orgName></list><tree><noCountry><name sortKey="Rodin, Rachel" sort="Rodin, Rachel" uniqKey="Rodin R" first="Rachel" last="Rodin">Rachel Rodin</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Jung, James J" sort="Jung, James J" uniqKey="Jung J" first="James J" last="Jung">James J. Jung</name></region><name sortKey="Cook, Deborah J" sort="Cook, Deborah J" uniqKey="Cook D" first="Deborah J" last="Cook">Deborah J. Cook</name><name sortKey="Fowler, Robert A" sort="Fowler, Robert A" uniqKey="Fowler R" first="Robert A" last="Fowler">Robert A. Fowler</name><name sortKey="Jouvet, Philippe" sort="Jouvet, Philippe" uniqKey="Jouvet P" first="Philippe" last="Jouvet">Philippe Jouvet</name><name sortKey="Kumar, Anand" sort="Kumar, Anand" uniqKey="Kumar A" first="Anand" last="Kumar">Anand Kumar</name><name sortKey="Long, Jennifer" sort="Long, Jennifer" uniqKey="Long J" first="Jennifer" last="Long">Jennifer Long</name><name sortKey="Marshall, John C" sort="Marshall, John C" uniqKey="Marshall J" first="John C" last="Marshall">John C. Marshall</name><name sortKey="Pinto, Ruxandra" sort="Pinto, Ruxandra" uniqKey="Pinto R" first="Ruxandra" last="Pinto">Ruxandra Pinto</name><name sortKey="Zarychanski, Ryan" sort="Zarychanski, Ryan" uniqKey="Zarychanski R" first="Ryan" last="Zarychanski">Ryan Zarychanski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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